Nanovector delivery of siRNA for cancer therapy
نویسندگان
چکیده
منابع مشابه
Multifunctional siRNA Delivery System for Cancer Therapy
The rationale for this study is to develop a multifunctional nanomedicine platform for siRNA targeted delivery to cancerous tumors as well as the use of MRI as a non-invasive strategy to monitor the drug therapy outcome. Therefore, we propose a novel multifunctional gene delivery vector by combining the magnetic properties of iron oxide nanoparticles and their ability to package siRNA strands i...
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Gene therapy has been recently shown as a promising tool for cancer treatment as nanotechnology-based safe and effective delivery methods are developed. Generally, genes are wrapped up in extremely tiny nanoparticles which could be taken up easily by cancer cells, not to their healthy neighboring cells. Several nanoparticle systems have been investigated primarily to address the problems involv...
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A polyelectrolyte complex (PEC) micelle-based siRNA delivery system was developed for treatment of cancer. A PEGylated siRNA targeting human vascular endothelial growth factor (hVEGF) was synthesized. The hVEGF expression was almost completely inhibited in vitro as well as in vivo by treating prostate cancer cells with the PEC micelles formed from the interaction between the conjugate and polye...
متن کاملsiRNA delivery systems for cancer treatment.
With increasing knowledge on the molecular mechanisms of endogenous RNA interference, small interfering RNAs (siRNAs) have been emerging as innovative nucleic acid medicines for treatment of incurable diseases such as cancers. Although several siRNA candidates for the treatment of ocular and respiratory diseases are undergoing clinical trials, there are challenges inherent in the further develo...
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ژورنال
عنوان ژورنال: Cancer Gene Therapy
سال: 2012
ISSN: 0929-1903,1476-5500
DOI: 10.1038/cgt.2012.22